Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects

• 作 者: She-Gan Gao Li-Dong Wang Zong-Min Fan Ji-Lin Li Xin He Rui-Feng Guo Dong-Ling Xie Xin-Wei He Shan-Shan Gao Hua-Qin Guo Jun-Kuan Wang Xiao-Shan Feng Bao-Gen Ma
• 机 构: Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou 450052, Henan P
• 出 处: 世界胃肠病学杂志（英文版）
• 发表日期: 2005年30期
• 关键词: Gastric cardia Intestinal metaplasia Histochemistry

AIM: To characterize the histochemical type and patt of intestinal metaplasia (IM) adjacent to gastric cardia adenocarcinoma (GCA) and distal gastric cancer (GC) in Linzhou, Henan Province, China.METHODS: Alcian-blue-periodic acid Schiff and high iron diamine-Alcian blue histochemical methods were performed on 142 cases of IM, including 49 cases of GCA and 93 cases of GC. All the patients were from Linzhou, Henan Province, China, the highest incidence area for both GCA and squamous cell carcinoma. Radio- or chemotherapy was not applied to these patients before surgery.RESULTS: The detection rate of IM in tissues adjacent to GCA tissues was 44.9%, which was significantly lower than that in GC tissues (80.64%, P<0.01). The rates of both incomplete small intestinal and colonic IM types identified by histochemistry in GCA tissues (31.82% and 63.64%, respectively) were significantly higher than those in GC (5.33% and 21.33%, respectively, P<0.01).CONCLUSION: IM in GCA and GC should be considered as a separate entity. Further research is needed to evaluate whether neoplastic progression of IM is related to its mucin profile in GCA.