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红霉素(EM)是临床常用抗生素,它通过抑制细菌的蛋白合成而发挥作用。常用剂量对绿脓杆菌感染无效。近年来,对从痰液中检出大量H流感病毒和绿脓杆菌的弥漫性细支气管炎,给以少量、长期投予红霉素治疗,取得了显著疗效。其作用机制不甚明确。绿脓杆菌可产生色素及一些外毒素,后者对人体产生毒性反应。作者首先提出红霉素可阻碍绿脓杆菌合成外毒素的假说,为此作者选择外毒素之一弹性蛋白酶,进行了实验研究。结果表明,EM对所试11株绿脓杆菌繁殖无影响,而能抑制其分泌弹性蛋白酶,其
Erythromycin (EM) is a clinically used antibiotic that works by inhibiting bacterial protein synthesis. Common doses of Pseudomonas aeruginosa infection is invalid. In recent years, a large number of Hib influenza virus and Pseudomonas aeruginosa detected from sputum diffuse bronchiolitis, given a small amount of long-term administration of erythromycin, and achieved significant results. Its mechanism is not clear. Pseudomonas aeruginosa can produce pigment and some exotoxins, which have toxic effects on the human body. The authors first proposed the hypothesis that erythromycin can hinder the synthesis of exotoxins from Pseudomonas aeruginosa. To this end, the authors selected one of the exotoxins, elastase, and conducted an experimental study. The results showed that EM had no effect on the 11 strains of Pseudomonas aeruginosa, but inhibited the secretion of elastase