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Objective: The aim of this study was to study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer. Methods: Sixty-eight cases of local advanced esophageal cancer were randomized into two groups, simple irradiation group (control group, n = 33) receiving conventional radiotherapy to a total of 60 Gy, combined group (research group, n = 35) which received the same radiotherapy as simple irradiation group plus chemotherapy with IP regimen, patients in research group were treated with infusion of Irinotecan 65 mg/m2 and DDP 30 mg/m2 on days 1 and 8. Twenty-one days was a cycle and 4 cycles were given. Results: The remission rate, one and two year disease-free survival rate in research group were significant higher than it in control group. But the incidence of nausea, vomiting, myelosuppression and diarrhea was higher in research group. Conclusion: The efficacy of concomitant radiotherapy and IP regimen for local advanced esophageal cancer is obviously and it can improve the survival rate of patients, which worthy of clinical application.
Objective: The aim of this study was to study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer. Methods: Sixty-eight cases of local advanced esophageal cancer were randomized into two groups, simple irradiation group (control group, n = 33) receiving conventional radiotherapy to a total of 60 Gy, combined group (research group, n = 35) which received the same radiotherapy as simple irradiation group plus chemotherapy with IP regimen, patients in research group were treated with infusion of Irinotecan 65 mg / m2 and DDP 30 mg / m2 on days 1 and 8. Twenty-one days was a cycle and 4 cycles were given. Results: The remission rate, one and two year disease-free survival rate in research group the significant higher than it in control group. But the incidence of nausea, vomiting, myelosuppression and diarrhea was higher in research group. Conclusion: The efficacy of concomitant radiotherapy and IP regimen for local advanced esophageal cancer is obviously and it can improve the survival rate of patients, which worthy of clinical application.