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本文报告157例Graves病患者六种自体抗体的测定结果,按临床表现、甲功测定及治疗情况分为未治组(甲)、治疗未控制或复发组(乙)、治疗缓解组(丙)三组。发现甲组患者TRAb、TgAb、TmAb、抗DNA抗体、ANA的阳性率分别为91.2、79.4、79.4、70.6及23.5％;抗体阳性率及结合率乙组与甲组比(除TBII P<0.05外)差异均无显著性;丙组与甲、乙两组相比其TRAb阳性率及TBII差异均有显著性(P<0.01),TmAb结合率与乙组比有显著差异(P<0.05),TgAb、TmAb、抗DNA抗体阳性率有显著差异(与甲组比P<0.01,与乙组比P<0.05);乙、丙两组IAb阳性率为5.6及4.2％。结果提示,Graves病患者血清中存有多种自体抗体,TRAb可作为检测Graves病及判断治疗效果和预后的一种可靠方法。经抗甲药物治疗后其IAb阳性率亦较高。
This article reports 157 patients with Graves disease six autoantibodies measured results, according to the clinical manifestations, the determination and treatment of thyroid function was divided into uncontrolled group (A), treatment of uncontrolled or relapsed group (B), remission of treatment group (C) Three groups. The positive rates of TRAb, TgAb, TmAb, anti-DNA antibody and ANA in group A were 91.2, 79.4, 79.4, 70.6 and 23.5% respectively. The antibody positive rate and binding rate were higher in group B than in group A (except TBII P <0.05 (P <0.01). The binding rate of TmAb was significantly different from that of group B (P <0.05). There was no significant difference between group C and group B The positive rates of TgAb, TmAb and anti-DNA antibody were significantly different (P <0.01 compared with group A, P <0.05). The positive rates of IAb in groups B and C were 5.6 and 4.2%, respectively. The results suggest that there are many autoantibodies in the serum of patients with Graves ’disease, and TRAb can be used as a reliable method for detecting Graves’ disease and judging the therapeutic effect and prognosis. After anti-A drug treatment of its positive rate of IAb is also higher.