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应用SP免疫组化方法研究nm23蛋白与p53蛋白在48例胃癌中的表达变化及其与胃癌的生物学行为及淋巴结转移的关系。结果显示：nm23低表达率为41．67％。nm23低表达与胃癌的浸润程度及癌细胞的增殖活性呈负相关（P＜0．05）.nm23低表达者淋巴结转移率明显高于nm23正常表达者（P＜0.05），p53阳性染色率为56．26％，p53阳性表达与胃癌的组织分型及浸润程度无关（P＞0．05），而与胃癌细胞的增殖活性呈正相关（P＜0．05）。p53阳性表达者淋巴结转移率明显高于p53阴性表达者（P＜0.05）。提示nm23等位基因缺失和p53基因突变在胃癌的淋巴结转移和肿瘤的浸润及增殖中起重要作用。
SP immunohistochemistry was used to study the expression of nm23 and p53 protein in 48 cases of gastric cancer, and their relationship with the biological behavior of gastric cancer and lymph node metastasis. The results showed that the nm23 low expression rate was 41.67%. The low expression of nm23 was negatively correlated with the invasive degree of gastric cancer and the proliferation of cancer cells (P<0.05). The lymph node metastasis rate of nm23 low expression was significantly higher than that of the normal expression of nm23 (P<0.05), and the positive rate of p53 staining was. At 56.26%, the positive expression of p53 was not related to the histological types and invasiveness of gastric cancer (P>0.05), but positively correlated with the proliferation of gastric cancer cells (P<0.05). The lymph node metastasis rate of p53 positive expression was significantly higher than that of p53 negative expression (P<0.05). It is suggested that the loss of nm23 allele and p53 gene mutation play an important role in lymph node metastasis and invasion and proliferation of gastric cancer.