论文部分内容阅读
应用免疫组织化学技术检测１０例正常子宫内膜、２２例不典型增生和４２例子宫内膜癌组织Ｐ１６蛋白的阳性表达率。结果显示，子宫内膜癌组织Ｐ１６蛋白阳性表达率为６９％，低于正常子宫内膜（１００％）和不典型增生组织（９１％）；高分化肿瘤的Ｐ１６蛋白阳性表达率高于低分化者，但Ｐ１６蛋白的阳性表达率与子宫内膜癌临床分期无关；子宫内膜癌患者Ｐ１６蛋白表达阴性者较阳性者预后差。提示Ｐ１６基因可能参与子宫内膜癌的发生，Ｐ１６蛋白表达可作为预测子宫内膜癌患者预后的一个重要指标。
Immunohistochemistry was used to detect the positive expression rate of P16 protein in 10 cases of normal endometrium, 22 cases of atypical hyperplasia and 42 cases of endometrial carcinoma. The results showed that the positive rate of P16 protein in endometrial carcinoma was 69%, lower than that in normal endometrium (100%) and atypical hyperplasia (91%). The positive rate of P16 protein in well differentiated tumor was higher than that in poorly differentiated tumor However, the positive expression rate of P16 protein was not related to the clinical stage of endometrial carcinoma. The positive expression of P16 protein in patients with endometrial carcinoma was poor. Suggesting that P16 gene may be involved in the occurrence of endometrial cancer, P16 protein expression can be used as an important indicator of prognosis in patients with endometrial cancer.