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目的探讨血管紧张素转换酶抑制剂(ACEI)对糖尿病(DM)大鼠血浆纤溶酶原激活物抑制剂1(PAI-1)和组织型纤溶酶原激活物(tPA)活性的影响及其机制。方法将链脲佐菌素诱导的DM大鼠分为正常对照组、培哚普利治疗组、培哚普利联合一氧化氮合酶(NOS)抑制剂治疗组。治疗4周后比较各组血浆PAI-1和tPA活性及PAI-1/tPA比值。结果与正常对照组相比,DM大鼠血浆PAI-1活性和PAI-1/tPA比值显著升高,tPA活性降低。培哚普利治疗使PAI-1活性下降,tPA活性增加。联合NOS抑制剂在一定程度上抵消了培哚普利的这种作用。结论 DM状态下存在纤溶异常,ACEI能够通过内源性的NO改善纤溶平衡。
Objective To investigate the effects of angiotensin converting enzyme inhibitor (ACEI) on plasma plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (tPA) activity in diabetic rats and Its mechanism. Methods Streptozotocin-induced DM rats were divided into normal control group, perindopril treatment group, perindopril combined with nitric oxide synthase (NOS) inhibitor treatment group. Plasma PAI-1 and tPA activity and PAI-1 / tPA ratio were compared between the four groups after treatment for 4 weeks. Results Compared with normal control group, plasma PAI-1 activity and PAI-1 / tPA ratio were significantly increased and tPA activity was decreased in DM rats. Perindopril treatment decreased PAI-1 activity and increased tPA activity. The combination of NOS inhibitors to some extent offset this effect of perindopril. Conclusion There is fibrinolytic abnormality in DM state. ACEI can improve fibrinolytic balance through endogenous NO.