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A novel complex of lanthanum(Ⅲ) with demethylcantharidate group (DCA), Na[La(DCA)_2(H_2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, ~1H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H_2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)_2(H_2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na_2DCA in vitro.
A novel complex of lanthanum (Ⅲ) with demethylcantharidate group (DCA), Na [La (DCA) _2 (H_2O)] was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligands, and on oxygen is from a H_2O. The antitumor activities of the complex against HL-60 human Leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na [La (DCA) _2 (H_2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na_2DCA in vitro.