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目的对比重型手足口病与危重型手足口病的特点,及早采取预防措施。方法采用对照研究,对比2014年收治的25例危重型和25例重型手足口病的白细胞、中性粒细胞、CRP、头颅MRI、淋巴细胞亚群情况。结果危重型手足口病的白细胞及中性粒细胞均较重型手足口病明显升高,且主要为脑干发生病变,重型手足口病头颅MRI未见明显异常。危重型淋巴细胞T及TH细胞较重型明显下降。结论对于出现神经系统病变的患儿,如果其白细胞及中性粒细胞明显升高,头颅MRI异常,淋巴细胞亚群T细胞及TH细胞明显降低,极有可能发展成为危重型手足口病并发生生命危险,应积极监测呼吸、循环功能,尽早干预,降低死亡率。
Objective To compare the characteristics of severe hand-foot-mouth disease and critically ill hand-foot-mouth disease and to take precautionary measures as soon as possible. Methods A control study was conducted to compare the leukocyte, neutrophil, CRP, head MRI and lymphocyte subsets in 25 critically ill patients and 25 severe HFMD patients admitted in 2014. Results Severe hand, foot and mouth disease of leucocytes and neutrophils are heavier hand-foot-mouth disease was significantly elevated, and mainly for the occurrence of brain stem lesions, head and neck disease of heavy hand-foot-mouth disease showed no significant abnormalities. Severe lymphocytes T and TH cells heavier decreased significantly. Conclusions In children with neurological diseases, if their leucocytes and neutrophils are significantly increased, abnormal MRI of the head, lymphocyte subsets T cells and TH cells are significantly reduced, it is very likely to develop into critical HFMD and occur Life-threatening, respiratory and circulatory function should be actively monitored and intervention should be initiated as soon as possible to reduce the mortality rate.