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目的观察清凉膏对肛肠手术后感染切口肉芽组织中血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管紧张素-2(angiopoientin-2,ANG-2)、CD34的表达和羟脯氨酸含量的影响。方法 42例肛肠手术患者随机分为对照组和清凉膏组,对照组患者术后创面用凡士林纱条外敷,清凉膏组用清凉膏纱条外敷,术后第3,7,14天取创面肉芽组织检测VEGF、ANG-2、CD34的表达和羟脯氨酸含量。结果术后治疗第7,14天的肉芽组织与治疗第3天比较,对照组和清凉膏组中VEGF、ANG-2、CD34蛋白的表达和羟脯氨酸含量逐渐增多(P<0.05);术后治疗第3,7天,清凉膏组与对照组在创面肉芽组织中VEGF、ANG-2、CD34蛋白表达和羟脯氨酸含量无明显差异;术后第14天,清凉膏组与对照组比较,创面肉芽组织中VEGF、ANG-2、CD34蛋白表达和羟脯氨酸含量明显增多(P<0.05)。结论清凉膏可能通过促进VEGF、ANG-2、CD34蛋白的表达和促羟脯氨酸含量增加发挥促进创面愈合的作用。
Objective To observe the effects of Qingliang Ointment on the expression of vascular endothelial growth factor (VEGF), angiopoientin-2 (ANG-2) and CD34 in granulation tissue after anorectal surgery and the content of hydroxyproline Impact. Methods 42 cases of anorectal surgery were randomly divided into control group and Qingliang paste group. In the control group, external application of Vaseline gauze was applied to the wounds of the control group. Cool cream paste gauze was applied externally on the wound surface. Granulation buds were applied on the 3rd, 7th and 14th days after operation Tissues were examined for VEGF, ANG-2, CD34 expression and hydroxyproline content. Results The expression of VEGF, ANG-2, CD34 protein and hydroxyproline content in the control group and Qingliang paste group were increased on the 7th and 14th day after the operation (P <0.05). There was no significant difference in the expression of VEGF, ANG-2, CD34 protein and hydroxyproline content in the wound granulation tissue between the Qingre cream group and the control group on the 3rd and 7th day after operation. On the 14th day after operation, The levels of VEGF, ANG-2, CD34 protein and hydroxyproline in wound granulation tissue were significantly increased (P <0.05). Conclusion Qingre Paste may promote the healing of wounds by promoting the expression of VEGF, ANG-2, CD34 and increasing the content of hydroxyproline.