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苯二氮类(Benzodiazepines)是目前临床上较常用的镇静剂之一。利眠宁最早于1955年合成,1959年安定问世,随后又合成了大量的衍生物:氟安定,硝基安定,氯硝基安定等。此类药物有镇静、抗惊厥及中枢肌肉松弛作用,临床上常用于烦躁不安、焦虑、紧张及失眠、抗惊厥和治疗癫闲。此类药物有成瘾性,长期用药突然停用可产生戒断症状,出现兴奋甚至惊厥。过量时中毒症状为运动失调,语言不清,重者昏迷和呼吸抑制。因此,做好其血药浓度的监测,有重要临床意见。本文就其含量测定方法简述如下:
Benzodiazepines are one of the most commonly used sedatives in clinical practice. Limendronate was first synthesized in 1955 and was stable in 1959. Then a large number of derivatives were synthesized: diazepam, nitrazepam, clonazepam and so on. Such drugs have sedation, anticonvulsant and central muscle relaxation, clinically used for irritability, anxiety, nervousness and insomnia, anticonvulsant and treatment of epilepsy. Such drugs are addictive, abrupt withdrawal of long-term medication can produce withdrawal symptoms, the emergence of excitement and even convulsions. Symptoms of overdose poisoning for the movement disorder, unclear language, severe coma and respiratory depression. Therefore, do a good job of monitoring blood concentration, there are important clinical opinions. This article on the determination of its content is summarized as follows: