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用反相HPLC法测定普鲁卡因和利多卡因的含量，并以外标法进行定量分析，采用238nm波长检测，Nova－ParC18柱，3．9×150mm，流动相甲醇－水－丁胺－冰醋酸（600：400：1．2：1V／F）。其中普鲁卡因的回收率99．76％，RSD0．530％。利多卡因回收率99．44％，RSD0．502％。其方法快速、准确、灵敏，样品处理简便易行。
The contents of procaine and lidocaine were determined by reversed-phase HPLC. Quantitative analysis was carried out by external standard method. The detection wavelength was 238 nm, Nova-ParC18 column, 3.9 × 150 mm, mobile phase methanol-water- Glacial acetic acid (600: 400: 1.2: 1 V / F). The recovery of procaine 99.76%, RSD 0.530%. Lidocaine recovery rate of 99.44%, RSD 0.502%. The method is rapid, accurate and sensitive, and sample processing is simple and easy.