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目的观察自拟疏肝健脾方联合质子泵抑制剂治疗胃食管反流病(GERD)的疗效。方法采取随机、单盲、阳性药对照的方法,将74例患者分配为疏肝健脾法联合雷贝拉唑组(治疗组)38例,双倍雷贝拉唑组(对照组)36例,2组均治疗6周,采用中医学证候标准调查表和胃食管反流病诊断问卷(Gerd Q)调查方法,观察2组治疗前后中、西医各临床症状积分变化,比较2组临床总疗效。结果治疗组总有效率为89.47%,对照组为77.78%,2组总有效率比较,差异有统计学意义(P<0.05);中医单项症状比较,2组治疗前后反酸、烧心症状比较差异无统计学意义(P>0.05),治疗组嗳气、咽紧不利、吞咽困难、胸背胀痛等症状疗效均优于对照组(P<0.05)。西医单项症状比较,2组间比较差异无统计学意义(P>0.05);在治疗前后,治疗组与对照组在各中西医单项症状中除恶心差异无统计学意义外(P>0.05),其余症状均有明显改善(P<0.05)。结论以疏肝健脾法联合雷贝拉唑中西医结合方法治疗GERD比单纯使用雷贝拉唑治疗疗效好,症状改善程度更大。
Objective To observe the effect of Shuganjianpi combined with proton pump inhibitor in the treatment of gastroesophageal reflux disease (GERD). Methods A randomized, single-blind, positive drug control method was used to divide 74 patients into 38 patients in the Shuganjianpi group combined with rabeprazole group (treatment group) and 36 patients in the double-rabeprazole group (control group) , Two groups were treated for 6 weeks. The TCM Syndrome Standard Questionnaire and Gerd Q Questionnaire were used to observe the changes of the scores of clinical symptoms in both groups before and after treatment. The total clinical scores of two groups were compared Efficacy. Results The total effective rate was 89.47% in the treatment group and 77.78% in the control group. The total effective rate in the two groups was statistically significant (P <0.05). Compared with the single symptoms of TCM, the symptoms of acid reflux and heartburn in the two groups were significantly different There was no statistical significance (P> 0.05). The curative effect of the symptom such as gallbladder irritation, dysphagia, dysphagia, chest and back pain were better in the treatment group than those in the control group (P <0.05). There was no significant difference between the two groups (P> 0.05). Before and after treatment, there was no significant difference between the treatment group and the control group in the single symptoms of Chinese and Western medicine except nausea (P> 0.05) Other symptoms were significantly improved (P <0.05). Conclusion Shuganjianpi method combined with rabeprazole traditional Chinese and western medicine treatment of GERD than the simple use of rabeprazole treatment effect is better, the degree of improvement is greater.