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将SD大鼠胸腺内预注射脾细胞抗原以诱导移植耐受，4～7d后行异位同种心脏移植，术后1周每天注射环抱素A10mg／kg。胸腺内牌细胞注射联合短期使用CsA组的移植心平均存活期较对照组显著延长，且抗原县为25X10’腺细胞来诱导耐受的效果较好。受体对供体靶细胞不表现出细胞介导的细胞毒作用。结果声明，经胸腺内注射异基因脾细胞，联合短期应用CSA能诱导免疫耐受，诱导耐受的抗原县以2.5X10’为好，且这种移植耐受是抗原特异性的，使移植物存活期明显延长。
SD rats were pre-injected with thymus spleen cell antigen to induce transplantation tolerance, 4 ~ 7d after ectopic allograft heart transplantation, 1 week after injection of cyclophilin A10mg / kg. The average survival time of intrathymus injection with short-term CsA group was significantly longer than that of control group, and the 25X10’gland cells in antigenic county were more effective in inducing tolerance. Receptors do not exhibit cell-mediated cytotoxicity on donor target cells. The results showed that intrathymic injection of allogeneic splenocytes combined with short-term application of CSA can induce immune tolerance, the induced tolerance of the county to 2.5X10 ’is good, and this transplant tolerance is antigen-specific, so that the graft Survival was significantly prolonged.