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通过原位造血重建的观察,发现骨内膜细胞及小梁内细胞很可能是支持造血细胞机能的基质细胞的源泉。本实验又以异位移植的造血重建的分析,进一步证实了异位移植的股骨可以而且能重建造血。在重建造血过程中,原有髓腔内的组织、细胞几乎全部变性和坏死,而小梁或皮质内细胞成分则增生活跃、进入髓腔,作为造血微环境的主要成分支持宿主迁徙来的造血干细胞的机能,从而完成造血重建过程。但经15Gy以上照射的移植物(股骨)则完全丧失诱导造血重建的微环境作用。
Through the observation of in situ hematopoietic reconstructions, it is found that the cells of the endothelium and the trabecular meshwork are likely to be the source of stromal cells that support the function of hematopoietic cells. In this experiment, the analysis of hematopoietic reconstructions with ectopic transplantation further confirmed that the ectopic transplantation of the femur can and can reconstruct the hematopoiesis. In the reconstruction of hematopoietic process, the original intramedullary tissue, cells almost all degeneration and necrosis, while the trabecular or cortical cellular components are proliferative, into the medullary cavity, as the main component of hematopoietic microenvironment to support the migration of host to hematopoietic Stem cell function, thus completing the hematopoietic reconstitution process. However, the graft (femur) irradiated by more than 15Gy completely lost the microenvironment effect of inducing hematopoietic reconstitution.