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目的探讨应用肺泡表面活性物质(PS)联合机械通气治疗早产儿呼吸窘迫综合征(NRDS)的效果。方法将94例呼吸窘迫综合征(NRDS)的早产儿随机分为两组,观察组早期给予气管内滴注肺泡表面活性物质(PS),随后进行机械通气;对照组不予肺泡表面活性物质治疗,比较两组患儿治疗效果、住院时间、氧疗时间、机械通气使用及并发症等情况。结果两组患儿治疗后血气分析结果较治疗前有显著改善,差异有统计学意义,观察组患儿的机械通气使用情况、呼吸机相关肺炎发生率、氧疗时间以及住院时间均较对照组低。结论早期应用PS联合机械通气治疗早产儿呼吸窘迫综合征(NRDS)的有效方式,能快速有效地改善肺功能,缩短氧疗时间及住院时间,减少相关并发症的发生。
Objective To investigate the effect of pulmonary surfactant (PS) combined with mechanical ventilation on respiratory distress syndrome (NRDS) in preterm infants. Methods 94 preterm infants with respiratory distress syndrome (NRDS) were randomly divided into two groups. The observation group received early intratracheal instillation of alveolar surfactant (PS), followed by mechanical ventilation. The control group received no alveolar surfactant treatment The treatment effect, hospitalization time, oxygen therapy time, the use of mechanical ventilation and complication were compared between the two groups. Results The results of blood gas analysis after treatment in both groups were significantly improved compared with those before treatment, the difference was statistically significant. The use of mechanical ventilation, the incidence of ventilator-associated pneumonia, oxygen therapy time and hospital stay in the observation group were significantly higher than those in the control group low. Conclusion The early application of PS combined with mechanical ventilation in the treatment of premature infants with respiratory distress syndrome (NRDS) is an effective way to quickly and effectively improve lung function, shorten the time of oxygen therapy and hospitalization, and reduce the incidence of complications.