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目的研究YB-1在宫颈癌中的高表达与宫颈癌病人预后的关系。方法用免疫组化方法,分析2002年1月～2009年1月经病理证实的46例宫颈癌标本组织中YB-1的表达,探讨YB-1与宫颈癌的关系,并用SPSS软件对结果进行分析。结果 YB-1高表达的宫颈癌患者复发率更高,并且有更短的无病进展期(P=0.035)和总的生存时间(P=0.013),多因素回归分析显示YB-1高表达是宫颈癌的独立预后因素。结论本项研究中,YB-1高表达患者预后差,YB-1高表达可能是宫颈癌独立预后因素。
Objective To study the relationship between the high expression of YB-1 in cervical cancer and the prognosis of patients with cervical cancer. Methods The expression of YB-1 in 46 specimens of cervical cancer confirmed by pathology from January 2002 to January 2009 was analyzed by immunohistochemistry. The relationship between YB-1 and cervical cancer was analyzed. The results were analyzed by SPSS software . Results The recurrence rate of YB-1-overexpressing cervical cancer patients was higher, with a shorter disease-free progression (P = 0.035) and overall survival (P = 0.013). Multivariate regression analysis showed that YB-1 overexpression Is an independent prognostic factor for cervical cancer. Conclusions In this study, patients with high expression of YB-1 had poor prognosis and high expression of YB-1 might be an independent prognostic factor for cervical cancer.