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采用随机、双盲对照法 ,将“军队多地域高血压抽样队列调查”检出的轻、中度高血压病患者 2 6 5例 (北京地区 37例 ,西藏地区 86例 ,海军 14 2例)分为比索洛尔组 (5mg/d)、依那普利组 (10mg/d)、缓释硝苯地平组 (2 0mg/d) ,治疗期限 4周。以诊室血压 (CBP)为指标比较三种药物的降压疗效 ,并观察不同地域对上述三种降压药物疗效的影响。结果表明 ,三种药物均能有效降低三个地域高血压病患者的CBP(P <0 0 5 )。北京地区、西藏地区和海军部队患者比索洛尔治疗的总有效率分别为 71 4 %、81 2 %和 83 0 % (P >0 0 5 )。西藏地区和海军患者依那普利治疗的总有效率分别为 96 0 %和 77 6 % (P <0 0 5 )。西藏地区和海军患者缓释硝苯地平治疗的总有效率分别为93 1%和 76 1% (P >0 0 5 )。
A total of 265 mild to moderate Hypertension patients (37 in Beijing, 86 in Tibet and 122 in the Navy) were detected by randomized, double-blind comparison. Divided into bisoprolol group (5mg / d), enalapril group (10mg / d), sustained release nifedipine group (20mg / d), the treatment period of 4 weeks. The clinic blood pressure (CBP) as an index to compare the antihypertensive efficacy of three drugs and observe the impact of different regions on the efficacy of the three antihypertensive drugs. The results showed that all three drugs can effectively reduce the CBP of three hypertensive patients (P <0 05). The total effective rates of bisoprolol in Beijing, Tibet and naval units were 71 4%, 81 2% and 83 0%, respectively (P 0 05). The total effective rate of enalapril treatment in Tibet and naval patients was 96 0% and 77 6%, respectively (P 0 05). The total effective rate of sustained-release nifedipine treatment in Tibet and naval patients was 93.1% and 76.1%, respectively (P> 0.05).