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[目的]评价转化生长因子βⅡ型受体(TβRⅡ)及Smad7在肺鳞癌组织中表达及其相关性。[方法]用Western blot法检测18例肺鳞癌癌组织及癌旁组织中TβRⅡ和Smad7的表达。[结果]TβRⅡ在癌组织的表达为癌旁组织的0.73倍(P<0.05),Smad7在癌组织表达是癌旁组织的3.6倍(P<0.05)。肺鳞癌组织Smad7和TβRⅡ表达呈负相关(r=-0.9173,P<0.05)。[结论]TβRⅡ低表达及Smad7过表达与肺鳞癌的发生密切相关。
[Objective] To evaluate the expression of transforming growth factor β receptor Ⅱ (TβRⅡ) and Smad7 in lung squamous cell carcinoma and their correlation. [Method] Western blot was used to detect the expression of TβRⅡ and Smad7 in 18 cases of lung squamous cell carcinoma and its adjacent tissues. [Results] The expression of TβRⅡ in cancer tissues was 0.73-fold (P <0.05) compared with that in para-cancerous tissues and 3.6-fold (P <0.05) in cancer tissues. The expression of Smad7 and TβRⅡ in lung squamous cell carcinoma was negatively correlated (r = -0.9173, P <0.05). [Conclusion] The low expression of TβRⅡ and Smad7 overexpression are closely related to the occurrence of squamous cell carcinoma of the lung.