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目的:探讨p53、bcl-2、bax基因在基底细胞样乳腺癌中的表达及其相互关系、临床意义。方法:选择基底细胞样乳腺癌(BLBC)43例、非基底细胞样乳腺癌(non-BLBC)57例、正常乳腺组织60例的标本,用免疫组化方法检测p53、bcl-2及bax蛋白的表达。结果:BLBC及non-BLBC中p53和bcl-2的表达水平都明显高于正常乳腺组织,bax表达水平低于正常乳腺组织,差异均有统计学意义(P<0.05);p53、bcl-2及bax在BLBC中的表达水平和患者年龄及肿瘤大小无关,与淋巴结转移情况及临床分期相关(P<0.05);p53与bcl-2表达呈正相关(r1=0.408),p53与bax、bcl-2与bax表达均呈负相关(r2=-0.578,r3=-0.408)。结论:p53、bcl-2和bax可能在基底细胞样乳腺癌的发生、发展中共同发挥作用。
Objective: To investigate the expression of p53, bcl-2 and bax genes in basal-like breast cancer and its relationship and clinical significance. Methods: 43 cases of basal-like breast cancer (BLBC), 57 cases of non-basal-like breast cancer (non-BLBC) and 60 cases of normal breast tissue were selected for immunohistochemical detection of p53, bcl-2 and bax protein expression. Results: The expression levels of p53 and bcl-2 in BLBC and non-BLBC were significantly higher than those in normal breast tissue, the expression of bax was lower than that in normal breast tissues (P <0.05) (P <0.05). The positive expression of p53 and bcl-2 (r1 = 0.408), the expression of p53 and bax, bcl-2 in BLBC were not related with the age of patients and tumor size, 2 and bax expression were negatively correlated (r2 = -0.578, r3 = -0.408). Conclusion: p53, bcl-2 and bax may play a role in the occurrence and development of basal-like breast cancer.