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目的分析C反应蛋白在指导绒毛膜羊膜炎临床治疗中的作用。方法将绒毛膜羊膜炎患者47例依据患者抗生素联用种类不同分为单联组24例,双联组23例。治疗前及入院后第1、2、3天给予酶联免疫吸附法检测血清C反应蛋白水平,观察2组患者治疗后C反应蛋白水平变化率。统计分析2组患者分娩后高热发生率及产后出血率。结果治疗前2组C反应蛋白水平差异均无统计学意义(P>0.05)。治疗后第1、2、3天2组C反应蛋白水平均低于治疗前,且双联组低于单联组,差异有统计学意义(P<0.05)。双联组第1、2、3天C反应蛋白变化率高于单联组,差异有统计学意义(P<0.05)。单联组患者分娩后高热发生率为12.5%(3/24),产后出血率为8.3%(2/24),均分别高于双联组的4.4%(1/23)和4.4%(1/23),差异均有统计学意义(P<0.05)。结论动态监测血清C反应蛋白水平变化有助于绒毛膜羊膜炎患者临床抗生素治疗效果判断;联合用药可能有助于降低绒毛膜羊膜炎患者并发症发生。
Objective To analyze the role of C-reactive protein in the clinical treatment of chorioamnionitis. Methods 47 cases of chorioamnionitis patients were divided into single group group (24 cases) and double group group (23 cases) according to the type of antibiotics. Serum C-reactive protein was detected by enzyme-linked immunosorbent assay before treatment and at 1, 2 and 3 days after admission, and the changes of C-reactive protein level in two groups were observed. The incidence of postpartum hemorrhage and postpartum hemorrhage were statistically analyzed in two groups. Results There was no significant difference in C-reactive protein levels between the two groups before treatment (P> 0.05). The levels of C-reactive protein in the two groups were lower than those before treatment on the 1st, 2nd, 3rd day after treatment, and were lower in the double combined group than in the single combined group (P <0.05). The change rate of C-reactive protein on the 1st, 2nd and 3rd day in the double combined group was higher than that in the single combined group, with significant difference (P <0.05). The incidence of high fever was 12.5% (3/24) and postpartum hemorrhage rate was 8.3% (2/24) in the single group, which were higher than 4.4% (1/23) and 4.4% (1/2) of the double group / 23), the differences were statistically significant (P <0.05). Conclusions The dynamic monitoring of serum C-reactive protein level is helpful to evaluate the effect of clinical antibiotics in patients with chorioamnionitis. Combined treatment may help to reduce the incidence of chorioamnionitis patients.