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Background Percutaneous coronary intervention(PCI) is a way of treating patients with coronary artery disease(CAD), especially for those with acute coronary syndrome(ACS). Previous studies have proved that the main complication of PCI is the injury caused by lipid peroxidation. The pathophysiology of lipid peroxidation is that with the revascularization of blocked coronary arteries by PCI, external oxygen enters the ischemic myocardial cells. As the activity of oxygen free radical scavenging enzyme decreases, oxygen free radicals are produced, resulting in lipid peroxidation damage on myocardial cell membrane. This study investigated the influence of hypertension(HBP) on PCI-induced lipid peroxidation in CAD patients. Methods Seventy patients with CAD were divided two groups: group A including 32 patients with CAD, and group B including 38 patients with CAD complicated with HBP. All patients received PCI. The plasma levels of malonaldehyde(MDA) and superoxide dismutase(SOD) were measured before PCI and 20 minutes, 24 hours, and 7 days after PCI respectively. The patients were followed up for cardiac events after PCI for 6 momths. Results The plasma levels of SOD and MDA were increased in both groups after PCI, but these changes were more in group B. On the 7th day the levels of SOD and MDA remained high in group B, whereas retained to the pre-operational levels in group A. During the follow-up of 6 months after the PCI, 4 patients were found to suffer from coronary restenosis, including one patient in group A(3.1%), and 3 patients in group B(7.8%).Conclusions The results suggest that PCI induces short-time free radical production in patients with CHD,especially in those complicated with HBP.
Background Percutaneous coronary intervention (PCI) is a way of treating patients with coronary artery disease (CAD), especially for those with acute coronary syndrome (ACS). Previous studies have proved that the main complication of PCI is the injury caused by lipid peroxidation. The pathophysiology of lipid peroxidation is that with the revascularization of blocked coronary arteries by PCI, external oxygen enters the ischemic myocardial cells. As the activity of oxygen free radical scavenging enzyme decreases, oxygen free radicals are produced, resulting in lipid peroxidation damage on myocardial cell This study investigated the influence of hypertension (HBP) on PCI-induced lipid peroxidation in CAD patients. Methods Seventy patients with CAD were divided two groups: group A including 32 patients with CAD, and group B including 38 patients with CAD complicated with HBP. All patients received PCI. The plasma levels of malonaldehyde (MDA) and superoxide dismutase (SOD) were measur The patients were followed up for cardiac events after PCI for 6 momths. Results The plasma levels of SOD and MDA were increased in both groups after PCI, but these changes were more in group B. On the 7th day the levels of SOD and MDA remained high in group B, but retained to the pre-operational levels in group A. During the follow-up of 6 months after the PCI, 4 patients were found to suffer from coronary restenosis, including one patient in group A (3.1%), and 3 patients in group B (7.8%). Conclusions The results suggest that PCI induces short-time free radical production in patients with CHD, especially in those complicated with HBP.