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为了解中药葛根的酒精提取物葛根素治疗血液高粘滞综合征，改善微循环的药理机制．方法：以血液高粘滞综合征病人做为研究对象，随机分为葛根素治疗组，及用其他抗凝药物治疗对照组，并以健康人群为正常对照，利用ＷＴ Ｐ－Ａ Ⅱ型可调试体外血栓形成及血小板粘附两用仪和ＳＤＩ－Ⅲ型血液自动计时粘度计检测等手段，观察葛根素和其他抗凝药物对血小板活化等方面的抑制作用．结果：表明葛根素在降低血小板粘附率，聚集率，改善血栓前状态，降低血液粘度等显著优于对照组，且不具备单一性，符合在体外／或体内有抑制血小板活化、抑制血小板血栓，又不引起出血的特点，且副作用小，使用安全，药源广阔，结论：葛根素可以做为一种抗栓，改善微循环的首选药物投入临床应用．
To understand the traditional Chinese medicine Kugen root alcohol extract puerarin treatment of blood hyperviscosity syndrome, improve the microcirculation pharmacological mechanisms. Methods: Patients with hyperviscosity syndrome were randomly divided into puerarin treatment group and control group with other anticoagulant drugs. The healthy volunteers were used as normal controls and WT P-A II type could be debugged. The inhibitory effect of puerarin and other anticoagulant drugs on platelet activation was observed by means of in vitro thrombosis and platelet adhesion assay and SDI-III blood automatic chronometer viscometer test. Results: It was shown that puerarin was superior to the control group in reducing the platelet adhesion rate, aggregation rate, improving the prethrombotic state, lowering the blood viscosity, etc., and did not have a single character, which was consistent with inhibiting platelet activation and inhibiting platelet thrombus in vitro and/or in vivo. , And does not cause bleeding characteristics, and side effects, the use of safe, wide range of sources, conclusion: puerarin can be used as an anti-thrombosis, improve the microcirculation of the preferred drug into clinical applications.