Thienorphine induces analgesia by binding κ -and δ-, or by partially binding μ-opioid receptor,thus

• 作 者: ZHOU Pei-lan LI Yu-lei YONG Zh
• 机 构: StateKeyLaboratoryofToxicologyandMedicalCountermeasures
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2018年9期
• 关键词: thienorphine OPIOID receptor ANALGESIA cAMP protein KINASE A
• 基金项目: National Natural Science Foundation of China(81473194,81773709).

OBJECTIVE Thienorphine, a new oripavine derivative, has shown to possess stronger antinociceptive effects and better oral bioavailability compared to buprenorphine. The present study examines the effect of thienorphine on cAMP-dependent protein kinase A (