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目的:探讨小剂量胺碘酮对急性心肌梗死(AMI)并高危快速型心律失常患者的临床疗效.方法:105例AMI并高危快速型心律失常患者随机分为2组;在AMI常规治疗的基础上,胺碘酮组:0.2G、每天3次,起效后减至每天1次口服,疗程3年.美托洛尔组:25~50MG,每天2次口服,疗程同上.结果:住院期间治疗组心肌梗死后心绞痛发生次数、静脉硝酸甘油剂量、用镇痛药次数均较美托洛尔组少(P＜0.05,P＜0.01),而左心室射血分数(LVEF)、左心室短轴缩短率(FS)、二尖瓣快速充盈期和心房收缩期二尖瓣血流速度(E/A)均较美托洛尔组高(P＜0.05,P＜0.01);泵衰竭发生率较美托洛尔组少(P＜0.05).随访3年,胺碘酮组发生不稳定型心绞痛、再发心肌梗死、心力衰竭均较美托洛尔组少(P＜0.05).结论:小剂量胺碘酮治疗AMI并高危快速型心律失常患者作用可靠、不良反应轻微,可作为预防再发梗死、改善预后的抗心律失常药物.“,”Objective:To investigate the efficacy of low dosage of amiodarone in treating acute myocardial infarction(AMI)with arrhythmia Methods:105 cases of AMI with arrhythmia were randomly assigned into two groups In the base of routine AMI therapy,patients in amiodarone group were treated with amiodarone 0 2 g three times daily for 5 to 7 days,followed by 0 2 g once daily for three years Patients in control group were given 25 mg to 50 mg of metopr...