论文部分内容阅读
目的探讨肾上腺皮质癌的临床病理学特征、诊断及鉴别诊断、治疗与预后。方法对6例肾上腺皮质癌进行临床资料、病理形态及免疫组化分析。结果肾上腺皮质癌6例,女性4例,男性2例,年龄23~60岁,平均53岁;功能性3例,无功能性3例。镜下可见瘤细胞异型明显,多边形,细胞质丰富,大部分嗜酸,核染色质呈粗颗粒状,可见核分裂象;瘤细胞呈巢、片状生长,可见侵犯包膜。免疫组化:肿瘤细胞melan-A、inhibin-α和p53(+),Cg-A(-),其中2例MSH2、MSH6(-),MLH1、PMS2(+)。结论肾上腺皮质癌的诊断,应将临床和病理形态学特征相结合,免疫组织化学具有重要的鉴别诊断作用。提高对肾上腺皮质癌的认识,对避免误诊是至关重要的。
Objective To investigate the clinicopathological characteristics, diagnosis, differential diagnosis, treatment and prognosis of adrenocortical carcinoma. Methods Six cases of adrenocortical carcinoma were studied by clinical data, histopathology and immunohistochemistry. Results 6 cases of adrenocortical carcinoma, 4 females, 2 males, aged 23 to 60 years, mean 53 years; 3 cases of functional, non-functional in 3 cases. Microscope showed abnormal atypia cells, polygons, cytoplasm rich, most of eosinophilic, chromatin was coarse particles, showing mitotic figures; tumor cells were nesting, flaky growth, showing violations of the envelope. Immunohistochemistry: melan-A, inhibin-α and p53 (+), Cg-A (-) were detected in tumor cells, including 2 cases of MSH2, MSH6 (-), MLH1 and PMS2 (+). Conclusion The diagnosis of adrenocortical carcinoma should be combined with clinical and pathological features, immunohistochemistry has an important differential diagnosis. Increasing awareness of adrenocortical cancer is crucial to avoiding misdiagnosis.