论文部分内容阅读
70年代初即知道口服避孕药能使血压升高数个mmHg,并使高血压患病率增加2～3倍。1971年曾报道这种效应与药片中孕激素的剂量有关,但其它研究者们发现造成该效应的是其中的雌激素。研究受孕调节方法的安全与功效的特别研究小组最近完成了一项多中心的研究,证实口服避孕药有血管降压作用,并提供了一些证据否定了口服避孕药中的雌激素成份能导致血压升高的假设。该研究用双盲法使用两种口服避孕药,各含雌激素(乙炔雌二醇,EE)50μg或30μg。两种药片也含有相同剂量的孕激素(LNG)250mg。该研究在六个中心进行:泰国的曼谷、印度的孟买、赞比亚的卢萨卡、菲律宾的马尼拉、古巴的圣地亚哥和匈牙利的塞格德。
Early 70s that oral contraceptives can make blood pressure increased several mmHg, and the prevalence of hypertension increased by 2 to 3 times. It was reported in 1971 that this effect was related to the dose of progestin in the tablets, but other investigators found that estrogen was responsible for this effect. A special multicenter study that examined the safety and efficacy of methods of control of conception pregnancy completed a vasoconstrictive study of oral contraceptives and provided some evidence that the estrogen component of oral contraceptives can cause blood pressure Raised assumptions. The study used two oral contraceptives in a double-blind fashion, each containing 50 μg or 30 μg of estrogen (ethinyl estradiol, EE). Both tablets also contained 250 mg of the same dose of progestogen (LNG). The study was conducted in six centers: Bangkok, Thailand; Mumbai, India; Lusaka, Zambia; Manila, the Philippines; Santiago, Cuba; and Szeged, Hungary.