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据报道,西米替丁可增加血清利多卡因总浓度的75%,因此有人在西米替丁与利多卡因联合用时,经验地将利多卡因输注速率减少50%。但是长期静注利多卡因和急性心肌梗塞的患者,血清利多卡因浓度也是增加的。心肌梗塞后,由于药物与α—1—酸性糖蛋白(AAG)结合,血清利多卡因总浓度的增高远较非结合型显著,为此有人对西米替丁—利多卡因相互作用的意义提出疑问。本文研究口服西米替丁对
Cimetidine has been reported to increase 75% of the total serum lidocaine concentration, so someone has experienced a 50% reduction in lidocaine infusion rate when cimetidine is administered in combination with lidocaine. However, long-term intravenous lidocaine and acute myocardial infarction patients, serum lidocaine concentrations also increased. After myocardial infarction, the increase of serum lidocaine concentration was much more than that of non-binding due to the binding of the drug to α-1-acid glycoprotein (AAG), and for this reason, the significance of the interaction of cimetidine-lidocaine ask a question. This article studies oral cimetidine