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目的：观察清毒退热药对内毒素性发热家兔血浆LPO含量和红细胞SOD活力变化，并对其进行分析。材料与方法：32只新西兰家兔，随机分为4组，Ⅰ组内毒素发热模型组，Ⅱ组内毒素加清毒退热药组，Ⅲ组清毒退热药组，Ⅳ组正常对照组。以硫代巴比妥酸法测定血浆LPO含量，以邻苯三酚法测定红细胞SOD活力。结果：清毒退热药不引起正常家兔体温下降；内毒素模型组血浆LPO含量明显高于其余各组（P＜0．01），红细胞SOD活力则低于其余3组（P＜0．01）。讨论：该研究说明清毒退热药具明显解热作用。提示：自由基参与内毒素诱导的过氧化反应过程；清毒退热药具有清除自由基、抗氧化、保护细胞的作用。
OBJECTIVE: To observe the changes of plasma LPO and erythrocyte SOD activity in rabbits with endotoxin-induced fever and to analyze them. Materials and Methods: Thirty-two New Zealand rabbits were randomly divided into 4 groups: Group I endotoxin fever model group, Group II endotoxin plus detoxification and antipyretic drugs group, Group III Qingdu antipyretic drugs group, Group IV normal control group . The thiobarbituric acid method was used to determine the plasma LPO content, and the erythrocyte SOD activity was measured by the pyrogallol method. Results: Qingdu antipyretic drugs did not cause the body temperature of normal rabbits to decrease; LPO content in the endotoxin model group was significantly higher than the other groups (P<0.01), and red blood cell SOD activity was lower than the other three groups (P<0. 01). Discussion: This study illustrates the apparent antipyretic effects of Qingdu antipyretics. Hint: Free radicals participate in the process of endotoxin-induced peroxidation; Qingdu antipyretic drugs have the effects of scavenging free radicals, antioxidation, and protecting cells.