MEG3a和MEG3基因与无功能性垂体腺瘤的研究进展

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MEG3a是功能未知的母本印记基因MEG3的新型转录产物,研究表明MEG3a在正常垂体组织中高表达,而几乎在全部无功能性垂体腺瘤、大部分功能性垂体腺瘤中不表达.同时,该基因的异位表达能抑制许多癌细胞株的增殖,包括Hela细胞,MCF-7和H4组蛋白等,因而它可能是一种抑癌基因,其生物学功能与细胞增殖有关.本文就MEG3和MEG3a基因与无功能性垂体腺瘤的关系作简要综述.
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