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目的观察丙戊酸钠单剂治疗儿童失神癫的疗效。方法选择1990-04—2004-05在首都儿科研究所儿童医院诊断失神癫并首选口服丙戊酸患儿123例,发作未能完全控制者加用氯硝西泮,观察其疗效并进行追踪。结果123例患儿中,丙戊酸单药治疗后发作完全控制者105例,发作完全控制率84.4%,其余18例单用丙戊酸发作未能完全控制者,加用氯硝西泮后,发作均得到完全控制,全部患儿发作完全控制率为100%。追踪34例停药后的患儿9个月至10年,其中2例复发,占5.9%。结论丙戊酸单药治疗失神癫能使84.4%的患儿发作完全控制,发作不能完全控制者应加用氯硝西泮,二者联合用药可使患儿的临床发作得到完全控制,且起效快。
Objective To observe the efficacy of sodium valproate in the treatment of children with absence of epilepsy. Methods 1990-04-2004-05 at the Capital Institute of Pediatrics Children’s Hospital diagnosis of absence of epilepsy and the preferred oral administration of valproic acid in 123 children, seizures failed to complete control plus clonazepam to observe its efficacy and follow-up . Results Among the 123 children, 105 cases were completely controlled by valproic acid monotherapy, the complete control rate was 84.4%. The remaining 18 cases were not completely controlled by valproic acid attack alone. After the addition of clonazepam , The seizures were completely controlled, and the complete control rate was 100% in all children. 34 cases were followed up for 9 months to 10 years after discontinuation, of which 2 cases recurred, accounting for 5.9%. Conclusion Valproic acid monotherapy in the treatment of absence of epilepsy can make 84.4% of children with complete control of seizures, seizures can not be completely controlled should be added with clonazepam, the combination of the two can make children with complete control of clinical seizures, and Fast onset.