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目的明确在多器官功能障碍综合征（ＭＯＤＳ）发病中胃肠道缺血性损害的作用。方法复习近年来的有关文献。结果严重创伤、失血性休克等导致的胃肠道血流量减少．粘膜内ｐＨ降低，以及肠道细菌过度生长等可引起肠粘膜通透性增加、内毒素血症和细菌移位。缺血还可使胃肠道粘膜产生ＴＮＦ、ＩＬ－６等细胞因子，导致胃、小肠和结肠动力障碍，并激活中性粒细胞导致局部和远隔脏器损伤。结论通过补液扩容、早期肠道营养、促进胃肠道动力等方法积极纠正胃肠道缺血，改善肠屏障功能，有助于防治ＭＯＤＳ。
Objective To clarify the role of gastrointestinal ischemic injury in the pathogenesis of multiple organ dysfunction syndrome (MODS). Methods to review the literature in recent years. The results of severe trauma, hemorrhagic shock and other gastrointestinal tract caused by decreased blood flow. Mucosal pH reduction, and intestinal bacterial overgrowth can cause increased intestinal mucosal permeability, endotoxemia and bacterial translocation. Ischemia can also make the gastrointestinal mucosa produce TNF, IL-6 and other cytokines, leading to gastric, intestinal and colon motility disorders, and activate neutrophils cause local and remote organs damage. Conclusions The methods of rehydration expansion, early gut nutrition, gastrointestinal motility and so on can positively correct gastrointestinal ischemia and improve intestinal barrier function, which is helpful to prevent and treat MODS.