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1987年,Palmer等和Ignarro等分别提出内皮细胞舒张因子的本质是一氧化氮(nitric oxide,NO)。目前,随着NO基础研究的进展,发现NO的生物学作用涉及到众多学科并参与机体的多种生理病理过程,现已成为国内外医学领域研究的热点和前沿之一。作为一重要的生理递质及化学信使,NO在新生儿肺损伤的发病过程中也扮演着重要角色。
In 1987, Palmer et al. And Ignarro et al. Respectively proposed that the intrinsic factor of endothelial relaxation factor is nitric oxide (NO). At present, with the progress of NO basic research, it is found that the biological role of NO involves in many disciplines and participates in many physiological and pathological processes of the body, and it has become one of the hot and frontiers in the field of medicine both at home and abroad. As an important physiological transmitter and chemical messenger, NO also plays an important role in the pathogenesis of neonatal lung injury.