Preparation of a Novel Calcium Phosphate Cement Using N-methylene Phosphonic Chitosan as a Gelling A

• 作 者: GENG Yanli RUAN Ziwei LI Dongx
• 机 构: Department of Materials Science and Technology
• 出 处: 武汉理工大学学报英
• 发表日期: 2004年期
• 关键词: N-methylene phosphonic chitosan calcium phosphate cement compressive strength

A modified chitosan ( N-methylene phosphonic Chitosan, NMPC ) was synthesized to improve solubility and ability to bind calcium ion. The properties of the raw material chitosan and its derivative NMPC were characterized using FTIR, 1 H-NMR. The aim of this study was to enhance the compressive CPC by reinforcing with NMPC. A formulation consisting of CPC powder, buffer solution and gelling agent was used for preparation of the CPC. CPC powder consisted of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous ( DCPA ). NMPC which acted as the gelling agent was dissolved iuto KH2 PO4 -Na2 HPO4 buffer solution. Each specimen in the mold was sandwiched between two fritted glass sides and kept for 24 hours. Compressive strengths were determined, the setting product was identified using X-ray diffraction and scanning electron microscopy was used to investigate the hydroxyapatite particles size and porosity. The experimental results showed that the dominating influence on the compressive strengths of CPC-NMPC was the HA particle size, its uniformity and appropriate porosity.