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目的通过检测血清游离脂肪酸在高血压病患者中的表达水平,探讨其在高血压病中的临床意义。方法回顾性分析高血压病患者100例,并选择同期的非高血压患者100例作为对照组。检测患者多项功能指标并进行分析。结果高血压病组患者腰臀比、收缩压、舒张压及心率均较对照组明显升高,差异有统计学意义(P<0.01);高血压病组患者甘油三脂、空腹血糖、空腹胰岛素、胰岛素抵抗指数及游离脂肪酸均高于对照组,差异有统计学意义(P<0.05);高血压病组患者左室舒张末期容量、左室质量指数和射血分数均较对照组差异有统计学意义(P<0.05)。经Pearson相关分析显示:腰臀比、收缩压、甘油三脂、空腹胰岛素、胰岛素抵抗指数、左室质量指数和射血分数与游离脂肪酸呈显著正相关(P<0.05)。结论高血压病患者常伴有游离脂肪酸浓度升高,具有一定相关性。检测游离脂肪酸对于高血压病的早期发现并及时干预具有重要意义。
Objective To investigate the clinical significance of serum free fatty acid in patients with essential hypertension by detecting its expression level. Methods A retrospective analysis of 100 cases of hypertensive patients, and select the same period of 100 cases of non-hypertensive patients as a control group. A number of patients with functional indicators and analysis. Results The WHR, systolic blood pressure, diastolic blood pressure and heart rate in hypertensive patients were significantly higher than those in the control group (P <0.01). The levels of triglyceride, fasting blood glucose, fasting insulin , Insulin resistance index and free fatty acid were higher than the control group, the difference was statistically significant (P <0.05); hypertension patients with left ventricular end-diastolic volume, left ventricular mass index and ejection fraction were statistically significant differences compared with the control group Significance (P <0.05). Pearson correlation analysis showed that waist-hip ratio, systolic blood pressure, triglyceride, fasting insulin, insulin resistance index, left ventricular mass index and ejection fraction were positively correlated with free fatty acid (P <0.05). Conclusion Hypertension patients often accompanied by elevated concentrations of free fatty acids, with some relevance. Detection of free fatty acids for the early detection of hypertension and timely intervention of great significance.