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目的:探讨慢性胃炎组织病理特征和Hp感染与慢性炎症程度的关系。方法:抽选我院2010年1月至2016年2月行胃镜检查诊断为慢性胃炎的467例患儿,作胃窦黏膜病理组织学检查,并检测有无HP感染,分析HP感染与慢性胃炎病理特征、慢性炎症程度之间的关系。结果:在病理检查中,轻度、中度、重度炎症反应患儿HP感染率(7.7%、41.2%、51.1%)依次升高,且差异具有统计学意义(P<0.05),有炎症活动度患儿的HP阳性率76.3%明显高于无炎症活动度患儿23.7%(P<0.05)。随着肠化分级加重、淋巴滤泡形成、萎缩程度分级升高等病理变化,Hp阳性率明显升高(P<0.05)。轻度、中度、重度炎症三组淋巴滤泡形成、肠化生和胃萎缩发生率明显呈递增趋势,Hp阳性率明显呈递增趋势,比较差异显著(P<0.05)。结论:Hp是慢性胃炎发病的重要影响因素,与患儿胃窦黏膜炎症程度、活动性、淋巴滤泡形成、肠化分级以及黏膜萎缩萎等病理变化密切相关。
Objective: To investigate the histopathological features of chronic gastritis and the relationship between Hp infection and chronic inflammation. Methods: A total of 467 children diagnosed as chronic gastritis by gastroscopy from January 2010 to February 2016 in our hospital were selected for histopathological examination of antral mucosa, and HP infection was detected. HP infection was compared with chronic gastritis Pathological features, the relationship between the degree of chronic inflammation. Results: In the pathological examination, the HP infection rate of children with mild, moderate and severe inflammatory reactions increased successively (7.7%, 41.2%, 51.1%), and the difference was statistically significant (P <0.05) The positive rate of HP in children was 76.3%, significantly higher than that in children without inflammatory activity (23.7%, P <0.05). With the increase of intestinal metaplasia, lymphoid follicles formation, atrophy degree and other pathological changes, Hp positive rate was significantly increased (P <0.05). The incidence of lymphoid follicles, intestinal metaplasia and gastric atrophy in the three groups of mild, moderate and severe inflammation showed an increasing trend, and the positive rate of Hp showed an increasing trend, with significant difference (P <0.05). Conclusion: Hp is an important factor in the pathogenesis of chronic gastritis. It is closely related to the pathological changes of antral mucosal inflammation, activity, lymphatic follicular formation, intestinal metaplasia and mucosal atrophy.