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目的:将2种药物治疗异位妊娠(EP)的临床资料(A组:中药,B组:中药+米非司酮RU486)进行研究,总结各自的适应症和疗效,以便寻找一种更优化的药物疗法。方法:对本院自2006—2010年住院收治179例(A组92例,B组87例)稳定型EP患者的临床资料进行系统性地回顾和统计分析。结果:适应症:两组患者的年龄、血β-hCG值、孕酮值及B超附件包块的大小等方面均无显著性差异(P>0.05)。疗效:两组的成功率无显著性差异(P>0.05),A组为63.04%(58/92),B组为67.82%(59/87)。在两组成功与失败的患者中血β-hCG值均有明显差异(均P<0.01);而血β-hCG的变化趋势、孕酮值P及B超附件包块等均无显著性差异(P>0.05)。结论:2种方法治疗成功的决定因素是患者血β-hCG值,中药(1216.15±2448.14)mIU/mL、中药+RU486(1022.72±1130.19)mIU/mL,而加用RU486并没有显示更多的益处,两组患者的适应症和治愈率无明显差异,其中住院时间A组更短。因此,对符合条件的患者,采用中药治疗可能更加适合,血β-hCG≤1200mIU/mL可作为其适应症的最重要指标。
OBJECTIVE: To study the clinical data of two kinds of drugs for treatment of ectopic pregnancy (group A: traditional Chinese medicine, group B: traditional Chinese medicine + mifepristone RU486) and summarize their respective indications and curative effects in order to find a more optimized Drug therapy. Methods: The clinical data of 179 patients with stable type EP admitted in our hospital from 2006 to 2010 were retrospectively analyzed and statistically analyzed. Results: Indications: There was no significant difference in age, blood β-hCG, progesterone value and the size of B-adnexal mass in both groups (P> 0.05). Efficacy: There was no significant difference in the success rate between the two groups (P> 0.05), A group was 63.04% (58/92), B group was 67.82% (59/87). There was significant difference of β-hCG between two groups of successful and unsuccessful patients (all P <0.01). There was no significant difference in β-hCG, progesterone P and B-adnexal mass (P> 0.05). Conclusion: The determinants of the success of the two methods are β-hCG, TCM (1216.15 ± 2448.14) mIU / mL and TCM + RU486 (1022.72 ± 1130.19) mIU / mL, Benefit, the two groups of patients with indications and cure rates no significant difference, of which hospital stay A group shorter. Therefore, for eligible patients, the use of traditional Chinese medicine may be more appropriate treatment, blood β-hCG ≤ 1200mIU / mL can be used as the most important indicator of its indications.