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目的:观察与分析布洛芬缓释胶囊的不良反应。方法:2014年10月~2016年2月之间共47例患者于我院应用布洛芬缓释胶囊治疗并发生不良反应,回顾性分析其临床资料,记录主要不良反应情况、发生时间、与性别和年龄的关系、治疗方法及效果。结果:本组患者发生的药物不良反应主要有单纯皮疹、尿痛、尿频和消化不良,用药后3~5d发生不良反应者占57.4%,比其他时段高,P<0.05;在40岁以下年龄段中,男性发病者占40.0%,高于女性,60岁及以上年龄段中,女性发病者占44.4%,高于男性;经过抗过敏等药物治疗,患者症状均消失。结论:布洛芬缓释胶囊的常见不良反应为过敏反应与肠道反应,医护人员要密切观察患者用药后的反应,特别要加强高发时段与高发人群的观察,合理用药,减少不良反应。
Objective: To observe and analyze the adverse reactions of ibuprofen sustained release capsules. Methods: From October 2014 to February 2016, 47 patients were treated with ibuprofen sustained-release capsules in our hospital. Adverse reactions were observed. The clinical data were retrospectively analyzed. The main adverse reactions, time of onset, Sex and age, treatment and effectiveness. Results: The patients had simple rash, dysuria, frequent urination and dyspepsia. Adverse reactions occurred in 3 to 5 days after treatment, accounting for 57.4%, higher than other periods (P <0.05). Under the age of 40 Paragraph, the incidence of male accounted for 40.0%, higher than women, aged 60 and over, the incidence of women accounted for 44.4%, higher than men; after anti-allergy and other drug treatment, the patient’s symptoms disappeared. Conclusion: The common adverse reactions of ibuprofen sustained-release capsules are allergic reaction and intestinal reaction. The medical staff should observe closely the reaction after the patient takes medication, especially to observe the high-incidence period and high-incidence population, reasonably use drugs and reduce adverse reactions.