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青霉素与头孢菌素均属β-内酰胺类抗生素,其分子结构有相似之处,故彼此间具一定的交叉过敏性,即对青霉素过敏者(包括皮试阳性者)应用头孢菌素后,有可能也发生过敏反应。但发生率低,约5％～10％,且引起过敏性休克等危及生命的严重反应较为罕见。由于这一原因,临床上对青霉素过敏者(包括皮试阳性者),如有明确的头孢菌素应用指征,可以改用头孢菌素。当然,在初次给药时,要特别注意观
Penicillin and cephalosporins are β-lactam antibiotics, the molecular structure of similarities, so each other with a certain degree of cross-sensitivity, that is, those who are allergic to penicillin (including skin test positive) cephalosporins, Allergens may also occur. However, the incidence is low, about 5% to 10%, and lead to serious life-threatening reactions such as anaphylactic shock is relatively rare. For this reason, clinical allergy to penicillin (including those who test skin positive), if there is a clear indication of cephalosporin application, you can switch to cephalosporins. Of course, in the initial administration, pay special attention