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目的:观察中药灌肠治疗小儿溃疡性结肠炎的临床疗效。方法:将43例湿热型结肠炎患儿随机分为灌肠组23例,对照组20例。对照组口服美沙拉嗪治疗,灌肠组口服美沙拉嗪加用清溃灌肠方药保留灌肠治疗。疗程3个月,观察两组治疗前后C反应蛋白(CRP)、血沉(ESR)、临床指数及疗效。结果:灌肠组总有效率高于对照组,有显著统计学差异(P<0.05);灌肠组各临床指数降低显著优于对照组,差异有统计学意义(P<0.05或P<0.01);治疗后灌肠组CRP低于对照组(P<0.05)。结论:联合清溃灌肠方治疗小儿溃疡性结肠炎能提高单纯口服美沙拉嗪缓释颗粒临床疗效。
Objective: To observe the clinical efficacy of traditional Chinese medicine enema in treating children with ulcerative colitis. Methods: Forty-three children with damp heat colitis were randomly divided into enema group (n = 23) and control group (n = 20). The control group oral mesalazine treatment, enema group oral mesalazine plus enema enema retention enema treatment. The course of treatment was 3 months. The C-reactive protein (CRP), ESR, clinical index and therapeutic effect were observed before and after treatment. Results: The total effective rate in the enema group was significantly higher than that in the control group (P <0.05). The clinical indexes in the enema group were significantly lower than those in the control group (P <0.05 or P <0.01). The CRP in the enema group after treatment was lower than that in the control group (P <0.05). Conclusion: The combined treatment of ulcerative colitis and ulcerative colitis can improve the curative effect of simple oral mesalazine sustained-release granules.