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为了探讨急性胰腺炎发生后胰腺感染的机理，将８０只大鼠分为两组：假手术组３０只；急性胰腺炎组５０只。两组大鼠又分五个亚组：分别于术后２４、４８、７２、９６及１４４ｈ处死大鼠。取肠系膜淋巴结、胰腺、门静脉血及盲肠内容物作细菌培养、菌种鉴定。另用６只正常大鼠作空白对照，光镜下观察肠粘膜形态。结果：①急性胰腺炎组术后肠系膜淋巴结和胰腺细菌阳性率明显高于假手术组；②急性胰腺炎后盲肠内大肠杆菌明显增多，盲肠内大肠杆菌数量与肠系膜淋巴结和胰腺部位的大肠杆菌阳性率直接相关；③急性胰腺炎组肠粘膜有糜烂、坏死、绒毛脱落现象。结果表明：急性胰腺炎后胰腺感染是由于肠道的细菌易位造成，早期主要经淋巴途径，主要易位细菌是大肠杆菌
In order to investigate the mechanism of pancreas infection after acute pancreatitis, 80 rats were divided into two groups: 30 in sham operation group and 50 in acute pancreatitis group. Two groups of rats were divided into five subgroups: rats were killed at 24, 48, 72, 96 and 144 h after surgery respectively. Take mesenteric lymph nodes, pancreas, portal vein blood and cecal contents for bacterial culture, strain identification. Another 6 normal rats as a blank control, light microscopic observation of intestinal mucosa morphology. Results: ① The positive rates of mesenteric lymph nodes and pancreatic bacteria in acute pancreatitis group were significantly higher than those in sham operation group. ② The number of E. coli in cecum was significantly increased after acute pancreatitis. The number of E. coli in cecum was higher than that in mesenteric lymph nodes and pancreas Rate is directly related to; ③ acute pancreatitis group intestinal erosion, necrosis, villous shedding phenomenon. The results showed that: pancreatic infection after acute pancreatitis is due to intestinal bacterial translocation caused by the early lymphatic pathways, the main translocating bacteria is Escherichia coli