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目的探讨达英-35与归肾丸合用治疗多囊卵巢综合征(PCOS)的疗效。方法将41例确诊的PCOS患者从月经第5天开始服用达英-35,每日1片,同时服用归肾丸,每天一剂,连服21 d为1个周期,停药待撤退性出血第5天开始下一周期。要求患者治疗前及治疗后月经第2~4天测定黄体生成素(LH)、促卵泡激素(FSH)、雌二醇、睾酮(T)、催乳素等生殖激素变化;治疗前及治疗后行B超检查,记录子宫大小、卵巢大小及卵泡数目,每月记录经量、痤疮、多毛的变化。结果 23例月经减少者中18例经量较前增多,26例痤疮者中19例治愈或基本治愈,19例多毛者有13例症状明显改善。血LH、FSH水平明显下降(P<0.01),LH/FSH恢复正常(P<0.01),T明显降低(P<0.05)。卵巢体积缩小,卵泡数明显减少(P<0.01)。结论达英-35与归肾丸联合应用治疗PCOS能有效改善症状,使异常升高的促性腺激素及雄激素恢复正常,不良反应少,疗效满意。
Objective To investigate the curative effect of Da Ying-35 combined with Guishen Pill in the treatment of polycystic ovary syndrome (PCOS). Methods 41 cases of diagnosed PCOS patients started taking Dayang-35 from the 5th day of menstruation, taking 1 pill daily and taking Guishen Pill once daily for 21 days for one cycle, stopping withdrawal withdrawal bleeding Day 5 begins the next cycle. Patients before and after treatment required 2 to 4 days menstrual luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, testosterone (T), prolactin and other reproductive hormones changes; before treatment and after treatment B-ultrasound, recording the size of the uterus, the size of the ovary and the number of follicles, menstrual flow per month, acne, hirsutism changes. Results Twenty-three of the 23 cases with reduced menstruation increased compared with the former group. Among 26 acne cases, 19 cases were cured or basically cured, while 13 cases had obvious improvement in 19 cases. Blood LH and FSH levels decreased significantly (P <0.01), LH / FSH returned to normal (P <0.01), T decreased significantly (P <0.05). Ovarian volume decreased, the number of follicles was significantly reduced (P <0.01). Conclusions Combination of Ying-35 with Guishen Wan can effectively ameliorate the symptoms and restore abnormally elevated levels of gonadotropins and androgen, with fewer side effects and satisfactory results.