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目的探讨口服地屈孕酮与肌内注射黄体酮治疗黄体功能不全的效果。方法选取2014年2月1日到2015年1月31日于我院妇产科就诊的黄体功能不全的患者共76例,将患者随机分为两组,A组和B组患者各38例,A组患者在本次研究中采用口服地屈孕酮的治疗方法,B组患者采用肌内注射黄体酮的治疗方法,比较两组患者的治疗效果及治疗不良事件发生状况。结果 (1)采用口服地屈孕酮治疗的A组38例患者的治疗总有效率为96%;采用肌内注射黄体酮治疗的B组38例患者总有效率为82.5%。对两组患者组间治疗效果进行检验,P>0.05,无统计学差异;(2)采用口服地屈孕酮治疗的38例A组患者,不良反应发生率为2.6%,采用肌内注射黄体酮的38例B组患者,不良反应发生率为15.8%,对两组患者组间不良反应发生率作X~2检验,P<0.05,有较强的统计学差异。结论临床上在黄体功能不全的患者时,可以采用口服地屈孕酮片的治疗方法。
Objective To investigate the effect of oral administration of progesterone and intramedical injection of progesterone on corpus luteum dysfunction. Methods A total of 76 patients with luteal insufficiency in obstetrics and gynecology department from February 1, 2014 to January 31, 2015 were selected and randomly divided into two groups, 38 patients in group A and group B, A group of patients treated with oral dydrogesterone in this study, B group treated with intramuscular injection of progesterone, the treatment effect of two groups of patients and treatment of adverse events were compared. Results (1) The total effective rate was 96% in group A treated with oral dydrogesterone. The total effective rate was 82.5% in group B treated with intramedullary progesterone. The treatment effect between the two groups of patients was tested, P> 0.05, no statistical difference; (2) 38 cases of A group treated with oral dydrogesterone treatment, the incidence of adverse reactions was 2.6%, intramuscular injection of luteal Ketones in 38 patients in group B, the incidence of adverse reactions was 15.8%, two groups of patients with adverse reactions for the X ~ 2 test, P <0.05, there is a strong statistical difference. Conclusions Clinically, in patients with corpus luteum insufficiency, oral treatment with progesterone tablets can be used.