论文部分内容阅读
目的 了解口腔颌面部鳞癌患者细胞免疫功能状态。方法 应用流式细胞术对19例口腔颌面部鳞癌患者及10例正常人外周血中T淋巴细胞亚群水平进行了检测。结果 口腔颌面部鳞癌患者外周血中的CD_3细胞数较健康人低下(P<0.05),CD4、CD4/CD8下降,而CD8升高。晚期、分化差及有颈淋巴结转移的患者,其CD3、CD4、CD4/CD8较早期、分化好及无颈淋巴结转移的患者低,而CD8则相对较高。结论 口腔颌面部鳞癌患者的细胞免疫功能低下,且可能与肿瘤的临床分期及病理分级有一定的关系。
Objective To understand the cellular immune function of oral squamous cell carcinoma patients. Methods T lymphocyte subsets in peripheral blood of 19 patients with oral squamous cell carcinoma and 10 normal controls were detected by flow cytometry. Results The number of CD_3 cells in peripheral blood of oral and maxillofacial squamous cell carcinoma patients was lower than that of healthy people (P <0.05), CD4, CD4 / CD8 decreased, while CD8 increased. Patients with advanced, poorly differentiated and cervical lymph node metastasis had lower CD3, CD4, CD4 / CD8 than those with early, well differentiated and no lymph node metastasis, while CD8 was relatively high. Conclusion The cellular immune function of oral and maxillofacial squamous cell carcinoma is low, and may have a certain relationship with the clinical stage and pathological grade of the tumor.