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目的研究原发性肝癌男性发病率高的原因。方法采用受体的放射配基结合分析法,检测30例手术病人肝癌及癌周组织和8例正常肝的胞浆及胞核的雄激素受体(AR)含量。结果胞核或胞浆AR的平均浓度为癌瘤>癌周组织>正常肝,差异有显著意义。肝癌及癌周组织的AR浓度与患者的性别、年龄、酗酒、乙肝表面抗原、丙肝抗体、甲胎蛋白,病理类型、细胞分化程度及基础肝病均无直接或间接关系。结论我国肝癌患者男性明显多于女性与肝癌表达AR可能有某种联系。
Objective To study the causes of high incidence of primary liver cancer in men. Methods Radioligand binding assay was used to detect the content of androgen receptor (AR) in the cytoplasm and nucleus of hepatocellular carcinoma, peri-cancerous tissue and 8 normal liver in 30 surgical patients. Results The average concentration of nuclear or cytoplasmic AR was significantly higher than that of carcinomas> pericarcinoma> normal liver. There was no direct or indirect relationship between the concentration of AR and the sex, age, alcoholism, hepatitis B surface antigen, hepatitis C antibody, alpha-fetoprotein, pathological type, degree of cell differentiation and basic liver disease. Conclusion There are obviously more men in HCC patients than those in women with HCC.