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目的对南海海绵Hyrtios erectus的高级性部分化学成分进行研究。方法对该种海绵的甲醇提取物按极性大小进行萃取,取正丁醇部分进行柱色谱,根据化合物的波谱数据及理化性质鉴定结构。结果分离得到5个吲哚类衍生物,分别为5-羟基色氨酸(Ⅰ),5-羟基吲哚-3-醛(Ⅱ),5-羟基吲哚-3-(2-羟基)乙基(Ⅲ),5-乙氧基吲哚-3-醛(Ⅳ),1-甲基-1,2,3,4-四氢-6-羟基-β-卡波啉-3-羧酸(Ⅴ)。结论所有化合物均为从该属海绵中首次分离。
Objective To study the chemical constituents of Hyrtios erectus in the South China Sea. Methods The methanol extract of this kind of sponge was extracted according to its polarity. The fraction of n-butanol was subjected to column chromatography. The structure was identified based on the spectral data and physical and chemical properties of the compound. Results Five indole derivatives were isolated and identified as 5-hydroxytryptophan (Ⅰ), 5-hydroxyindole-3-aldehyde (Ⅱ) (III), 5-ethoxyindole-3-aldehyde (IV), 1-methyl-1,2,3,4-tetrahydro-6-hydroxy-β-carbopolinic acid (V). Conclusion All the compounds were isolated from this sponge for the first time.