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目的:研究口腔扁平苔藓(oral lichen planus,OLP)患者损害组织中浸润的T细胞受体(T cell receptor,TCR)BV基因的取用格局。方法:采用实时定量聚合酶链反应,分析OLP患者损害组织中浸润的T细胞和外周血中T细胞TCR BV基因的取用格局。采用GraphPad Prism version 5.00软件对数据进行Mann-Whitney U检验。结果:43例OLP患者的损害组织对BV4、BV14和BV18基因的取用显著高于39例OLP患者外周血对这些BV基因的取用。结论:OLP患者损害组织浸润的T细胞优势取用BV4、BV14和BV18基因,提示带有BV4、BV14和BV18基因的T细胞参与了OLP的发病。
Objective: To investigate the pattern of BV gene infiltration in Tissue Implants (TCR) in patients with oral lichen planus (OLP). Methods: Real-time quantitative polymerase chain reaction (PCR) was used to analyze the pattern of TCR BV gene in infiltrating T cells and peripheral blood of OLP patients. Data were Mann-Whitney U test using GraphPad Prism version 5.00 software. RESULTS: The lesions of 43 patients with OLP were significantly higher in BV4, BV14 and BV18 genes than in 39 OLP patients. CONCLUSION: The predominant T cells in infiltrating Tissues infiltrating Tissue from infiltrating tissues of OLP patients take BV4, BV14 and BV18 genes, suggesting that T cells with BV4, BV14 and BV18 genes are involved in the pathogenesis of OLP.