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以改进的Hummers法制得的氧化石墨烯为原料,利用其表面羧基,用聚乙烯亚胺(PEI)和透明质酸(HA)对其进行表面修饰,采用核磁共振(~1 H-NMR)、透射电镜(TEM)、热重分析仪(TGA)及Zeta电位测试对所制备的载体进行表征。并装载抗肿瘤模型药物阿霉素,考察了其在不同pH条件下的药物体外释放行为。结果表明:透明质酸被成功修饰到氧化石墨烯上,而并不改变氧化石墨烯本身的片层结构,且制备的新型抗肿瘤药物载体具有pH敏感释放的功能。
Using modified Hummers’ method of graphene oxide as raw material, surface carboxyl groups were modified by polyethyleneimine (PEI) and hyaluronic acid (HA) The prepared carriers were characterized by transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and Zeta potential measurements. And loaded with anti-tumor drug doxorubicin, investigated its in vitro release behavior under different pH conditions. The results showed that hyaluronic acid was successfully modified to graphene oxide without changing the lamellar structure of the graphene oxide itself, and the novel antitumor drug carrier prepared had the function of pH-sensitive release.