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国外学者1968年首次报道应用大剂量氯甲蟀吟（MTX）合并应用甲酸四红叶酸钙（CF）解救方法治疗转移性骨肉瘤获得成功。被称为MTX治疗恶性肿瘤史上一次剂量革命。在此之后用于治疗骨肉瘤，疗效大大提高。国内王继苦用该方法做骨肉瘤术前、术后治疗。取得很好效果。我院对2例骨恶
Foreign scholars reported for the first time in 1968 that the use of high-dose clomazone (MTX) combined with the use of formic acid tetra- fulvonic acid (CF) to rescue metastatic osteosarcoma was successful. A dose revolution called MTX in the history of malignant tumors. Since then, it has been used to treat osteosarcoma and its efficacy has been greatly improved. Domestic Wang Ji used this method to do osteosarcoma preoperative and postoperative treatment. Get good results. Our hospital has 2 cases of bone evil