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目的探讨小剂量阿司匹林联合氯吡格雷应用于缺血性脑血管疾病临床治疗中的效果。方法 120例缺血性脑血管病患者,根据治疗方式不同分为研究组和对照组,各60例。对照组单用氯吡格雷,研究组在对照组基础上加用小剂量阿司匹林。比较两组患者临床疗效,并记录两组患者不良反应发生情况。结果研究组显效37例、有效18例、无效5例,总有效率为91.67%,对照组显效27例、有效19例、无效14例,总有效率为76.67%,两组总有效率比较差异具有统计学意义(P<0.05)。研究组患者中出现2例胃肠道反应、3例过敏反应,其不良反应发生率为8.33%;对照组患者中出现1例胃肠道反应、2例过敏反应,其不良反应发生率为5.00%;两组不良反应发生率比较差异无统计学意义(P>0.05)。结论小剂量阿司匹林联合氯吡格雷治疗缺血性脑血管疾病疗效肯定,不良反应少,用药安全性高,值得临床推广应用。
Objective To investigate the effect of low-dose aspirin combined with clopidogrel in the clinical treatment of ischemic cerebrovascular disease. Methods A total of 120 patients with ischemic cerebrovascular disease were divided into study group and control group according to different treatment methods, 60 cases each. Control group with clopidogrel alone, the study group in the control group based on the use of low-dose aspirin. The clinical efficacy of the two groups was compared and the incidence of adverse reactions was recorded in both groups. Results In the study group, 37 cases were markedly effective, 18 cases were effective, 5 cases were ineffective and the total effective rate was 91.67%. In the control group, 27 cases were markedly effective, 19 cases were effective and 14 cases were ineffective. The total effective rate was 76.67%. There was significant difference between the two groups Statistically significant (P <0.05). There were 2 cases of gastrointestinal reaction and 3 cases of allergic reaction in the study group, the incidence of adverse reactions was 8.33%. One case of gastrointestinal reaction and two cases of allergic reaction were found in the control group. The incidence of adverse reactions was 5.00 %; There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Low-dose aspirin combined with clopidogrel for the treatment of ischemic cerebrovascular disease is effective, less adverse reactions, high drug safety, it is worth promoting the clinical application.